Butylated hydroxytoluene (E321, BHT) is a synthetic antioxidant used to stabilize fats and oils. EFSA set an ADI of 0.25 mg/kg bw/day in 2012. While permitted in the EU and US, mechanistic and high‑dose animal data suggest endocrine, hepatic, and tumor‑promotion effects, so we grade it ORANGE — Some Concerns.